Research Center

Oral Health Clinical Research Center

The mission of the Oral Health Clinical Research Center (OHCRC) is to enhance oral health by transferring basic and applied research knowledge and new technical advances into patient-oriented research. This would enhance the diagnosis, prevention, and treatment of oral diseases.

To make an appointment, or to receive more information about our research studies, please see the studies below.

Current studies in need of participants

The School of Dentistry is currently recruiting individuals to participate in several ongoing studies. We welcome interested individuals to contact the study coordinator listed with each of the below studies if you would like to know more about these studies and learn what you would be asked to do. All studies have been reviewed and approved by the University of Minnesota’s Institutional Review Board (IRB).  

A study for individuals who suffer with chronic TMJ/ Jaw Pain that significantly interferes with their daily activities?

A study for individuals who suffer with chronic TMJ/ Jaw Pain that significantly interferes with their daily activities?

Study Title: Brain Mechanisms Underlying Endogenous Pain Modulation in Chronic TMJD

PI: Estephan Moana-Filho DDS, MS, PhD   Sponsor: NIH/NIDCR

This study is assessing if the brain of individuals with chronic jaw pain process touch and pain stimulation to their gums, face and hands differently than individuals with no jaw pain. 

Timeline:

Visit 1: Questionnaire and exam (90 minutes)
School of Dentistry Research Clinic      

Visit 2: Questionnaires, exam, impressions of teeth and bite registration (180 minutes) 
School of Dentistry Research Clinic

Visit 3: Questionnaires, exam and MRI of the brain (120 minutes)
Center for Magnetic Resonance Research, Minneapolis Campus                 

Major Inclusion Criteria:

  • Females between the ages of 18 to 65 years old
  • Have chronic jaw pain present for ≥ 6 months and this pain interferes with daily activities

Major Exclusion Criteria:

  • Current pain medications that cannot be stopped 1 day prior to testing
  • Conditions/diseases associated with altered pain perception including neurological disorders, multiple sclerosis, trigeminal neuralgia, neoplasia, psychiatric disorders, diabetes, and neoplasm
  • Serious injury to hands that prevent testing them
  • Substance abuse
  • MRI contraindications including claustrophobia and pregnancy

Compensation:  $200.00 to be paid for completion of all 3 visits and voucher for parking.

How to get involved or to learn more? Contact:

Contact: Lauren Huffman, huffm052@umn.edu

A study for individuals in need of tooth-colored fillings - The Composite Study

A study for individuals in need of tooth-colored fillings - The Composite Study

Study Title: In vivo Assessment of the Tooth-Resin Composite Interface Using Optical Coherence Tomography or The Composite Study

PI: Dr. Hooi Pin Chew           Sponsor: UMN SOD Veden Grant

The purpose of the study is to compare two ways to prepare your tooth for a filling. But, it is hard to see the microscopic changes to a filling clinically. We want to look at your filling with a special tool to see how the edges of a filling change over 18 months. This tool will help us to evaluate the edges of you filling.

Timeline: Potential participants will first be screened at the dental school by the study investigator to look at the tooth requiring a filling. Qualifying University of Minnesota (UMN) dental school patients will attend four (4) appointments at the UMN School of Dentistry over 18 months. First visit will include an in-person screening to make sure they meet the study requirements. Once screened, participants will be scheduled for an appointment to place a biting surface composite (tooth colored) filling with two additional visits to monitor and record data about the filling. These follow-up visits will occur 6 and 18 months after the filling is placed.

Compensation: A total of $160 will be paid in the form of Target gift cards; $10 at in-person screening, $20 at procedure appointment, $50 at 6 months, and $80 at 18 months after the filling is placed. In addition, parking vouchers will be provided at the end of each appointment.

Inclusion Criteria:
Patient level:

  • 18 years or older
  • Good general health
  • Fair oral hygiene
  • At least 20 teeth in occlusion
  • Available for the duration of the study

Exclusion Criteria:
Patient level:

  • Signs of bruxism / teeth grinding

Interested participants contact Kelli Trauger at blan0207@umn.edu or 612-624-2231.

Evaluating the performance of a new FDA-approved dental adhesive (bond) in tooth-colored fillings sponsored by 3M

Evaluating the performance of a new FDA-approved dental adhesive (bond) in tooth-colored fillings sponsored by 3M

PI: Dr. Jorge Perdigao

Sponsor: 3M Company

The investigational device in this research study is Scotchbond™ Universal Plus (SBU+) Adhesive, which is manufactured by 3M. The intended purpose of SBU+ Adhesive is to be used as a bond-promoting substance between the tooth and dental restorations. It may also be used as a dentin sealant and as a bonding agent for repair of restorations. The comparator product (i.e., Control product) for the investigational device will be Scotchbond™ Universal (SBU) Adhesive, which is also manufactured by 3M.

The purpose of this research study is to compare SBU+ Adhesive with its predicate device (SBU Adhesive) in relation to functional aspects of the restorations. The follow-up period of 6, 12, and 24 months is based on previous 2-year studies of other composite resin adhesives showing differences in retention, fracture, and marginal adaptation scores.

Timeline: Patients will first be screened at the dental school by the study dentist to look at teeth requiring dental fillings. Qualifying patients will attend five (5) appointments at the University of Minnesota (UMN) School of Dentistry (SOD) over 24 months. First visit will include an in-person screening to make sure they meet eligibility requirements. Once screened, participants will be scheduled for an appointment to place two composite (tooth colored) fillings using the 3M dental adhesives with three (3) additional follow-up visits after the fillings are placed at 6, 12, and 24 months to record data on each tooth.

Compensation: A total of $300 will be paid in the form of a debit card; $50 after the filling appointment, $50 at 6-months, $100 at 12-months, and $100 at 24-months. In addition, up to $12 of parking will be  validated at the Washington Avenue Ramp on campus at the end of each appointment.

Inclusion Criteria:

  1. Between the ages of 18 and 70 years old at time of consent
  2. Needs at least two direct composite restorations for posterior Class I or Class II carious lesions in vital teeth that are asymptomatic and with minimal mobility (< 1 mm in the buccolingual direction) 
  3. Study teeth have a minimum buccolingual diameter of the occlusal surface that is at least 1/3 of the distance between the buccal and lingual cusps
  4. Teeth selected for Class II restorations need to have an adjacent tooth in a position that will allow for a contact relationship to be established
  5. Needs to read and understand the English language without assistance
  6. Available for all scheduled study visits for the duration of 24 months
  7. Good general health (i.e., meets ASA Level I or ASA Level II classification criteria)
  8. The selected teeth need to have occlusal contact with an antagonistic natural tooth
  9. Has existing radiographic images of the study teeth of current and acceptable diagnostic quality obtained within the previous 12 months (i.e., needs to be a patient of record at the UMN SOD)

Exclusion Criteria:
Preoperative exclusion criteria include the following:

  1. Has a history of adverse reaction to any materials used in this study
  2. Is pregnant or breast feeding at the time of screening
  3. Fewer than 20 teeth
  4. Is taking part in or planned to be enrolled in an evaluation of other restorative materials at any time during the study
  5. Advanced periodontal disease (i.e., Grace & Smales Mobility Index grade ≥ 2) that involve the study teeth
  6. Orthodontic appliance treatment within the previous 3 months
  7. Pronounced enamel wear facets, indicting severe, on-going bruxism
  8. Severe xerostomia
  9. The study tooth has a history of or existing, prolonged tooth hypersensitivity
  10. The study tooth is an abutment for fixed or removable prostheses
  11. The study tooth has a fracture or is visibly cracked such that it may impact the longevity of the tooth
  12. The carious lesion is stage RC5 or RC6 of the ICDAS radiographic scoring system
  13. Unable to understand study procedures or provide consent in English
  14. Is an employee or student of the study investigator(s)

Intraoperative exclusion criteria include the following:

  1. Pulp exposure of either study tooth during restoration procedure

Do you have a patient who qualifies? Contact Kelli Trauger at blan0207@umn.edu