Research Center

Oral Health Clinical Research Center

The mission of the Oral Health Clinical Research Center (OHCRC) is to enhance oral health by transferring basic and applied research knowledge and new technical advances into patient-oriented research. This would enhance the diagnosis, prevention, and treatment of oral diseases.

To make an appointment, or to receive more information about our research studies, please see the studies below.

Current studies in need of participants

The School of Dentistry is currently recruiting individuals to participate in several ongoing studies. We welcome interested individuals to contact the study coordinator listed with each of the below studies if you would like to know more about these studies and learn what you would be asked to do. All studies have been reviewed and approved by the University of Minnesota’s Institutional Review Board (IRB).  

A study to test if placing an antibiotic on your gums treats gum disease better than just cleaning your teeth

A study to test if placing an antibiotic on your gums treats gum disease better than just cleaning your teeth

This study is comparing deep cleaning of your teeth with and without minocycline – an antibiotic - for treatment of gum disease over a 6-month period. Saliva from your mouth, fluid around your teeth, and blood will be collected at each of the four study visits.

Timeline:

Qualifying participants will receive one deep cleaning at the beginning of the study and two additional teeth cleanings at 3 and 6 months after the start of the study – with no cost to you.  Participants will be randomized – like a flip of a coin – between having the antibiotic or not. Appointments will be 1-3 hours long - typically scheduled on Wednesdays.

Major Inclusion Criteria:

  • Be at least 21 years old
  • Have gum disease (determined when you come in)
  • Need deep teeth cleaning
  • Willingness to fulfill all study requirements

Major Exclusion Criteria:

  • Had a deep cleaning in the last six months
  • Cigarette use within the last year
  • Long-term antibiotic use
  • Pregnant, planning to become pregnant, or unsure of pregnancy status and mothers who are breastfeeding
  • Diagnosed cardiac conditions, any uncontrolled medical conditions, or immunocompromised
  • Tetracycline allergy, or taking medication that effects gum tissues

Compensation:

Payment is available for completion of each study visit. You could receive a total of $200 for completing all study visits.

How to get involved? Contact:

Danna Hickey, RDH, MSDH at hicke097@umn.edu or (612) 626-4744

Michelle Arnett, RDH, BS, MS at marnett@umn.edu or (612) 624-3457

Sponsor: Bausch Health Co.

A study for individuals with gum disease around their teeth or dental implant(s).

A study for individuals with gum disease around their teeth or dental implant(s).

PI: Massimo Costalonga DMD, PhD                   Sponsor: Schaffer Chair Fund

This study is determining if specific compounds in the fluid around teeth or implants is different in individuals with advanced gum disease compared to individuals with no gum disease. 

Timeline: 

  • 5 visits over a 2-year period (i.e., Beginning of study, and then at 6, 12, 18 and 24 months after the start of the study).
  • At each visit, the gum around your teeth or implant(s) will be examined, fluid will be collected from around your teeth or implant(s), and an x-ray of your teeth or implant will be taken. 

Major Inclusion Criteria:

  • Have advanced gum disease involving your teeth or implant(s)

Major Exclusion Criteria:

  • Uncontrolled systemic disease, such as diabetes 
  • Use of antibiotics within the past 3 months
  • Treatment of your gums in the past 12 months 

Compensation:  $35.00 at each visit.

How to get involved or to learn more? Contact:  

Patt Carlson GDH, BS, CCRP, study coordinator, at carls006@umn.edu or 612-624-9669.

A study for individuals who suffer with chronic TMJ/ Jaw Pain that significantly interferes with their daily activities?

A study for individuals who suffer with chronic TMJ/ Jaw Pain that significantly interferes with their daily activities?

PI: Estephan Moana-Filho DDS, MS, PhD   Sponsor: NIH/NIDCR

This study is assessing if the brain of individuals with chronic jaw pain process touch and pain stimulation to their gums, face and hands differently than individuals with no jaw pain. 

Timeline:

Visit 1: Questionnaire and exam (90 minutes)
School of Dentistry Research Clinic      

Visit 2: Questionnaires, exam, impressions of teeth and bite registration (180 minutes) 
School of Dentistry Research Clinic

Visit 3: Questionnaires, exam and MRI of the brain (120 minutes)
Center for Magnetic Resonance Research, Minneapolis Campus                 

Major Inclusion Criteria:

  • Females between the ages of 18 to 65 years old
  • Have chronic jaw pain present for ≥ 6 months and this pain interferes with daily activities

Major Exclusion Criteria:

  • Current pain medications that cannot be stopped 1 day prior to testing
  • Conditions/diseases associated with altered pain perception including neurological disorders, multiple sclerosis, trigeminal neuralgia, neoplasia, psychiatric disorders, diabetes, and neoplasm
  • Serious injury to hands that prevent testing them
  • Substance abuse
  • MRI contraindications including claustrophobia and pregnancy

Compensation:  $200.00 to be paid for completion of all 3 visits and voucher for parking.

How to get involved or to learn more? Contact:

Patt Carlson GDH, BS, CCRP, study coordinator, at carls006@umn.edu or 612-624-9669.